Bcl6 reporter mice for immune memory research
Immune memory is the immune system to produce a higher-affinity antibody rapidly for antigens which have been exposed previously. This system is utilized at vaccination, and so on. However, the dynamic mechanism is little known. The transcription factor B–cell lymphoma 6 (Bcl6) reporter mice was established for elucidation of antibody production mechanism in vivo. Immune memory occurs at the germinal center (GC), which is formed in the secondary lymphoid organs for immune response. Bcl6 regulates the development of both GC B cells and follicular helper T (Tfh) cells in the GC.
|Depositor||:||Takaharu Okada, Ph.D.
Laboratory for Tissue Dynamics
RIKEN Center for Integrative Medical Sciences
|References||:||||Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, Okada T. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity.; 34(6): 961-972, 2011.|
|||Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, Kurosaki T. T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.Immunity.; 48(4): 702-715, 2018.|
Contact: Saori Mizuno, Ph.D.
Experimental Animal Division, RIKEN BioResource Research Center
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