Cre Transgenic Mouse Series_1

RIKEN BRC June 2006
Mouse of the Month
Cre Transgenic Mouse Series_1
Cre recombinase is a 38 kDa enzyme derived from the bacteriophage P1 which specifically recognizes 34 bp loxP sites. Cre has been shown to effectively mediate the excision of DNA flanked by loxP sites. Cre-loxP system is a very useful tool for time-space-specific knock-out the genes which can not be investigated in adults because of their embryonic lethality in conventional gene-targetting.


BRC No. 01153 Six3-Cre mouse
Six3-Cre Promoter : Sine oculis-related homeobox 3
Application : Neurobiology
Expression : developing retina and ventral forebrain
Depositor : Dr. Yasuhide Furuta
(Univ. of Texas)
BRC No. 01153 TgN(Six3 Cre)22Frt
BRC No. 01154 TgN(Six3 Cre)69Frt
BRC No. 01297 DBH-Cre mouse
DBH-Cre Promoter : Dopamin beta hydroxylase
Application : Neurobiology
Expression : typical noradrenergic and adrenergic cell groups, transient catecholaminergic cell types
Depositor : Dr. Kazuto Kobayashi
(Fukushima Medical Univ.)
BRC No. 01297 DBH-Cre/6-8
BRC No. 01492 DBH-Cre/9-9
BRC No. 01342 Emx1-Cre mouse
Emx1-Cre Promoter : Empty spiracles homolog 1
Application : Neurobiology
Expression : dorsal telencephalon, neocortex, hippocampus, and olfactory bulb
Depositor : Dr. Shigeyoshi Itohara
BRC No. 00808 Emx1-Cre
BRC No. 01342 Emx1-Cre Tg1
BRC No. 01343 Emx1-Cre Tg2
BRC No. 01344 Emx1-Cre Tg3
BRC No. 01345 Emx1-Cre KI Δneo

Comments are closed.