Card15/Nod2 KO mouse

RIKEN BRC June 2007
Mouse of the Month


Card15/Nod2 KO mouse
A model for Crohn’s disease

BRC No. 01869_Card15 KO
Research Application : Immunology and Inframmation
BRC No. 01869_Card15 KO


  Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors that affect host-microbe interactions and production of inflammatory mediators. The Card15/Nod2 gene has been identified as the first susceptible gene for CD. The Card15 deficient mice show hyper activation in immune system caracterized by increased cytokine production and bigger Peyer’s patches. This strain is useful as an animal model for Crohn’s disease.


Depositor : Dr. Marco Giovannini
(INSERM, France)
Reference : PLoS ONE., 2007 Jun 13;2:e523.

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