BRC facility Health Report
Update information
IMPC Search IMPC database

Frequently used strains and publications


Quality Control

Technical information

Customer service


  Order Form


Video protocol

Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

Jun 2008 Drs KO Mouse


Drs KO Mouse
A Key Molecule for Tumor Suppression

BRC No. RBRC02435 B6.Cg-Srpx<tm1Hzi>
Research Application : Apoptosis Research
Cancer Research
RBRC02435 B6.Cg-Srpx<tm1Hzi>


  The Drs (downregulated by v-src) gene is originally found as a novel suppressor of v-src transformation. The Drs gene expresses in most normal tissues, however the expression is completely downregulated in a variety of cancer cell lines and tissues. It has been shown that malignant tumors such as lymphomas, lung adenocarcinomas and hepatomas were generated in about 30% of the Drs KO mice between 7 and 12 months. The Drs KO embryonic fibroblasts also showed enhanced sensitivity to transformation by viral oncogenes. Reintroduction of Drs gene into a tumor cell line derived from the tumor of the Drs KO mouse suppresses tumorigenesis and enhances caspase-mediated apoptosis.


Depositor :  Dr. Hirokazu Inoue (Shiga University of Medical Science) (Japanese page)
Reference :  Carcinogenesis. 2007 28(4):777-84.