Hairless Congenics for Dermatology Studies
A: Donor Hos:HR-1 mice. Homozygous hairless mother and shedding littermates at 18 days old. B: B6.HR1-Hrhr/Rbrc at 22 days. C: MSM.HR1-Hrhr/Rbrc at 24 weeks. D: C.HR1-Hrhr/Rbrc at 26 weeks. E: C3.HR1-Hrhr/Rbrc at 10 weeks.
The homozygous Hrhr
mutant mouse is widely used in dermatological studies as various skin tests can be conducted without shaving [1, 2]. To utilize the hairless characteristics in various genetic backgrounds, four congenic strains of the Hrhr
gene have been generated by using the Hos:HR-1 mouse as the donor strain and performing successive backcrossing to C57BL/6JJcl (RBRC01223), BALB/cAnNMs (RBRC01417), C3H/HeNCrlj (RBRC01418) and MSM/MsRbrc (RBRC01222) strains as the recipients. The Hos:HR-1 donor strain has been established at HOSHINO LABORATORY ANIMALS, CORP. (Masayuki Hoshino, President) from Skh:HR-1 mice imported in 1987 from Temple University Skin and Cancer Hospital, Philadelphia, United States. The homozygous Hrhr
mutant exhibits hair loss after growth of the first hair coat and does not grow a second coat. Shedding of hairs starts around the nose at 14 days of age and spreads posteriorly to the base of the tail. ALOPECIA UNIVERSALIS CONGENITA (OMIM ID: 203655
) is caused by a mutation in the human homolog of the mouse “hairless” (HR) gene. These hairless congenic mice are therefore useful for various dermatological studies.
||Dr. Atsushi Yoshiki, Experimental Animal Division, RIKEN BioResource Center
||Brooke HC, Hairless mice, J Hered 17:173-174, 1926.
||Sundberg JP (ed.), Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools, 1994.