p27 KO mouse

RIKEN BRC October 2006
Mouse of the Month
p27 KO mouse
Big mouse with multiple tumor

BRC No. 01878_B6;129P2-Cdkn1btm1Kin
Targeted mutation : p27Kip1, Chr 6
Gene Symbol : Cdkn1b (OMIM600778)
Research Application : Cell Cycle and Tumor Biology
(upper) p27 KO mouse
(right) Pathological abnormality in the retina
of p27 KO mouse. Allows indicate the invaded outer
granular layer cells into the rods and cones.


  p27Kip1 is one of the the inhibitor for a series of cyclin and cyclin-dependent kinase (CDK) complex which plays a central role in the regulation of cell cycle progression. p27Kip1-deficient mice display a variety of abnormalities such as increased body size with their enlarged organs and disorganized layer pattern in retina (Figure right). About half of mutants develop tumors originating from the intermediate lobe of pituitary gland by 12 weeks of age. This strain is useful for cell cycle research and tumor biology.


Depositor : Dr. Kei-ichi Nakayama
(Kyushu University)
Reference :  Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Shishido, N., Horii, I., Loh, D. Y., and Nakayama, K.
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.
Cell. 1996 May 31;85(5):707-20.

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