Visualizing Histone H2A Variants in Chromatin
There are several variants of histone H2A that change in chromatin composition during genome remodeling after fertilization. These flag epitope-tagged histone H2A variant transgenic mouse lines were generated to investigate the dynamics of the canonical histone H2A and its 3 variants, H2A.X, H2A.Z, and macroH2A. These transgenic mice are clearly useful to visualize changes of histone H2A variants in chromatin during oogenesis and pre-implantation development.
|Depositor||:||Dr. Fugaku Aoki, The University of Tokyo|
|Reference||:||Nashun B, Yukawa M, Liu H, Akiyama T, Aoki F. Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice. Development.;137(22):3785-94, 2010.|