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RIKEN BioResource Research Center Mouse E-mail News No. 158
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RIKEN BioResource Research Center (BRC) is pleased to update you with the
latest information.
======= Contents =======================================================
- Special topic: Mouse of the Month
"Cas9 Tg mice to realize efficient genome editing mouse production"
- Today's model for human disease
- IMPC production paper has been published
- User publications
- Newly deposited mouse strains
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| Special topic: Mouse of the Month
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Cas9 Tg mice to realize efficient genome editing mouse production
RBRC10984 B6;B6D2-Tg(CAG-hCas9)2Saku
Depositor: Takayuki Sakurai, Ph.D.
Shinshu University
https://mus.brc.riken.jp/en/mouse_of_month/may_2021_mm
Mouse of the Month archive
https://mus.brc.riken.jp/en/mouse_of_month
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| Today's model for human disease
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Downstream factor of IL-17 signaling pathway Nfkbiz (IκB-ζ) floxed mice
RBRC06410 B6.Cg-Nfkbiz<tm1.1Muta>
Tyrosine kinase receptor family EphB6 KO mice
RBRC02280 B6.129S4-Ephb6<tm1Tom>
ROS1-fusion positive lung cancer model mice
RBRC09696 C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
RBRC09697 C57BL/6J-Tg(SFTPC-SDC4/ROS1)141Tno
Glycolysis enzyme PKM (pyruvate kinase M) mutant mice
RBRC10481 B6.Cg-Pkm<tm1Ntan>
RBRC10482 C57BL/6-Pkm<tm3Ntan>
Today's model for human disease
https://mus.brc.riken.jp/en/todays_tool_and_model
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| IMPC production paper has been published
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"A resource of targeted mutant mouse lines for 5,061 genes", Nature Genetics
https://doi.org/10.1038/s41588-021-00825-y
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| User publications
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The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.
RBRC01345 B6.129P2-Emx1<tm1.1(cre)Ito>/ItoRbrc
Nagashima S, Ito N, Kobayashi R, Shiiba I, Shimura H, Fukuda T,
Hagihara H, Miyakawa T, Inatome R, Yanagi S.
Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3
leads to immature dentate gyri and hyperactivity in mice.
J Biol Chem. 2021 Mar 31;100620. doi: 10.1016/j.jbc.2021.100620.
https://doi.org/10.1016/j.jbc.2021.100620
RBRC02189 C57BL/6Cr-Tg(Pcdh21-cre)BYoko
RBRC02933 C57BL/6-Tg(Olfr16-Olr226*D126R/R127D,-EYFP)1Hsak
Inoue N, Nishizumi H, Ooyama R, Mogi K, Nishimori K, Kikusui T, Sakano H.
The olfactory critical period is determined by activity-dependent
Sema7A/PlxnC1 signaling within glomeruli.
Elife. 2021 Mar 29;10:e65078. doi: 10.7554/eLife.65078.
https://doi.org/10.7554/eLife.65078
RBRC02975 B6.129S-Atg5<tm1Myok>
Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH,
Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH.
Platelet autophagic machinery involved in thrombosis through a novel
linkage of AMPK-MTOR to sphingolipid metabolism.
Autophagy. 2021 Apr 5;1-18. doi: 10.1080/15548627.2021.1904495.
https://doi.org/10.1080/15548627.2021.1904495
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| Newly deposited mouse strains
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Dr. Tadashi Yamamoto, Okinawa Institute of Science and Technology Graduate University
RBRC11289 B6.129-Btg3<tm1Tya>
RBRC11290 B6.129-Lmtk2<tm1Tya>
RBRC11291 B6.129-Lyn<tm1Tya>
RBRC11292 B6.129-Nyap1<tm1Tya>
RBRC11293 B6.129-Nyap2<tm1Tya>
RBRC11294 B6.129-Myo16<tm1Tya>
RBRC11295 B6.129-Nyap1<tm1Tya> Nyap2<tm1Tya> Myo16<tm1Tya>
RBRC11296 B6;129-Ptpn4<tm1Tya>
Dr. Reiko Kobayakawa, Kansai Medical University
RBRC11329 B6-Del(16Olfr187-Olfr196)1Kob
RBRC11330 B6-Tg(Olfr1353-GAP/CFP,-icre)1Kob
Dr. Fugaku Aoki, The University of Tokyo
RBRC11357 B6.B6D2-H2ax<em1Ibbr>
RBRC11358 B6.B6D2-H2ac1<em1Ibbr>
Dr. Ryuichi Nishinakamura, Kumamoto University
RBRC11359 B6.129-Sall1<tm1Ryn>
RBRC11360 B6;129-Sall1<tm4.1Ryn>/#166-29
RBRC11361 B6;129-Sall1<tm4.1Ryn>/#166-25
RBRC11362 B6;129-Sall2<tm1Ryn>
Dr. Yuji Takahashi, Tokyo University of Pharmacy and Life Sciences
RBRC11377 C57BL/6-Atf5<em1(Atf5/HA)Yuta>
RBRC11378 ICR-Atf5<em2(Atf5/HA)Yuta>
https://mus.brc.riken.jp/en/mailnews/kitaku_list/20210420_k
__________________________________________________________________
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__________________________________________________________________
RIKEN BioResource Research Center
Experimental Animal Division
3-1-1 Koyadai, Tsukuba-shi
Ibaraki, 305-0074 Japan
animal.brc@riken.jp
https://mus.brc.riken.jp/en/
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2021.05.19.
