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BRC Mouse E-mail News No. 185
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RIKEN BioResource Research Center (BRC) is pleased to update you with the
latest information.
======= Contents =======================================================
- Mouse of the Month "Oxytocin Receptor (Oxtr) functional analysis tools"
- Today's model for human disease
- Today's tool for functional analysis
- User publications
- New Collaborative papers
- Newly deposited mouse strains
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| Mouse of the Month
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Oxytocin Receptor (Oxtr) functional analysis tools
B6;Cg-Oxtr<em1(1xPA/T2A/tdTomato)Yinn> (RBRC11686)
B6;Cg-Oxtr<em2(1xPA/T2A/icre)Yinn> (RBRC11687)
B6;Cg-Oxtr<em3(3xPA)Yinn> (RBRC11688)
B6;Cg-Oxtr<em4(3xHA/T2A/icre/ERT2)Yinn> (RBRC11689)
Depositors: Takayoshi Inoue, Ph.D. and Yukiko U. Inoue, Ph.D.
(National Center of Neurology and Psychiatry)
https://mus.brc.riken.jp/en/mouse_of_month/sep_2023_mm
Mouse of the Month archive
https://mus.brc.riken.jp/en/mouse_of_month
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| Today's model for human disease
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A molecular chaperon Serpinh1(Hsp47) floxed mice
RBRC10972 B6.Cg-Serpinh1<tm2Kzn>
A molecular chaperon Serpinh1(Hsp47) KO mice
RBRC10971 B6.Cg-Serpinh1<tm1Kzn>
A TNF superfamily Tnfsf11 (RANKL) floxed mice
RBRC06142 B6.129-Tnfsf11<tm1>
A transmembrane protein Pmepa1 mutated mice
RBRC11387 C57BL/6N-Pmepa1<em1Akt>
https://mus.brc.riken.jp/en/todays_tool_and_model
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| Today's tool for functional analysis
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Zeb2 (SIP1, Zfhx1b) gene fluorescent reporter mice
RBRC09239 ICR;129(Cg)-Zeb2<tm2.1Yhi>
RBRC09240 STOCK Zeb2<tm2.1Yhi>
Sox9 gene fluorescent reporter mice
RBRC05651 B6;129-Sox9<tm1Haak>
Tg mice for conditional overexpression of SOX9
RBRC05654 B6.Cg-Tg(CAG-mRFP1,-SOX9,EGFP)1Haak
Tg mice for misexpression of SOX9 in limb bud mesenchyme
RBRC05525 B6.B6D2-Tg(Prrx1-Sox9,-lacZ)1Haak
https://mus.brc.riken.jp/en/todays_tool_and_model
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| User publications
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The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.
https://rrc.nbrp.jp/references/register
RBRC09240 STOCK Zeb2<tm2.1Yhi>
Kim S, Chen J, Jo S, Ou F, Ferris ST, Liu TT, Ohara RA, Anderson DA, Wu R, Chen MY, Gillanders WE, Gillanders WE, Murphy TL, Murphy KM.
IL-6 selectively suppresses cDC1 specification via C/EBPβ.
J Exp Med. 2023 Oct 2;220(10):e20221757. doi: 10.1084/jem.20221757.
https://doi.org/10.1084/jem.20221757
RBRC01834 C57BL/6-Tg(CAG-flpe)36Ito/ItoRbrc
Takubo K, Htun PW, Ueda T, Sera Y, Iwasaki M, Koizumi M, Shiroshita K, Kobayashi H, Haraguchi M, Watanuki S, Honda ZI, Yamasaki N, Nakamura-Ishizu A, Arai F, Motoyama N, Hatta T, Natsume T, Suda T, Honda H.
MBTD1 preserves adult hematopoietic stem cell pool size and function.
Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2206860120. doi: 10.1073/pnas.2206860120.
https://doi.org/10.1073/pnas.2206860120
RBRC00144 B6.SJL-Ptprc<a>/Rbrc
(RCB1283) B16 melanoma
(RCB1933) NALM-6
(RCB0027) K562
Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A.
SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine.
Cell Rep. 2023 Aug 8;112940. doi: 10.1016/j.celrep.2023.112940.
https://doi.org/10.1016/j.celrep.2023.112940
RBRC00886 B6;B6C3-Tg(Acro3-EGFP)01Osb
Hashimoto K, Odaka H, Ishikawa-Yamauchi Y, Nagata S, Nakamura H, Kimura H, Sato T, Makiyama K, Ogawa T.
Culture-space control is effective in promoting haploid cell formation and spermiogenesis in vitro in neonatal mice.
Sci Rep. 2023 Jul 31;13:12354. doi: 10.1038/s41598-023-39323-y.
https://doi.org/10.1038/s41598-023-39323-y
RBRC00144 B6.SJL-Ptprc<a>/Rbrc
Sano T, Ueda K, Minakawa K, Mori T, Hashimoto Y, Koseki H, Takeishi Y, Ikeda K, Ikezoe T.
Impaired Repopulating Ability of Uhrf2-/- Hematopoietic Progenitor Cells in Mice.
Genes. 2023, 14(8):1531. doi: 10.3390/genes14081531.
https://doi.org/10.3390/genes14081531
RBRC02330 NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>
Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H.
Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.
NPJ Vaccines. 2023 Jul 24;8(1):106. doi: 10.1038/s41541-023-00700-3.
https://doi.org/10.1038/s41541-023-00700-3
RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs>
Ho H, Kejzar N, Sasaguri H, Saito T, Saido TC, De Strooper B, Bauza M, Krupic J.
A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.
Cell Rep Methods. 2023 Jul 13;3(7):100532. doi: 10.1016/j.crmeth.2023.100532.
https://doi.org/10.1016/j.crmeth.2023.100532
RBRC01346 C57BL/6-Prkdc<scid>/Rbrc
Kemmotsu N, Zhu L, Nagasaki J, Otani Y, Ueda Y, Dansako H, Fang Y, Date I, Togashi Y.
Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models.
Cancer Sci. 2023 Jul 23. doi: 10.1111/cas.15911.
https://doi.org/10.1111/cas.15911
RBRC04495 B6.Cg-Tg(Tek-cre)1Ywa
Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, Mori Y, Kaneko S, Shirakawa H.
The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production.
Sci Adv. 2023 Jul 21;9(29):eadh0102. doi: 10.1126/sciadv.adh0102.
https://doi.org/10.1126/sciadv.adh0102
RBRC10053 B6(Cg)-Aqp4<tm1.1Tsna>
Serizawa K, Miyake S, Katsura Y, Yorozu K, Kurasawa M, Tomizawa-Shinohara H, Yasuno H, Matsumoto Y.
Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice.
J Neuroimmunol. 2023 Jul 15;380:578109. doi: 10.1016/j.jneuroim.2023.578109.
https://doi.org/10.1016/j.jneuroim.2023.578109
RBRC10149 B6.B6D2-Tg(Mafg-Nfe2l1)1Mym
Wang Y, Snell A, Dyka FM, Colvin ER, Ildefonso C, Ash JD, Lobanova ES.
Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness.
Sci Adv. 2023 Jul 14;9(28):eadd5479. doi: 10.1126/sciadv.add5479.
https://doi.org/10.1126/sciadv.add5479
RBRC02975 B6.129S-Atg5<tm1Myok>
Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Taminishi S, Nishiji T, Taruno A, Fukui M, Arany Z, Matoba S.
Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.
Nat Commun. 2023 Jul 13;14(1):4084. doi: 10.1038/s41467-023-39404-6.
https://doi.org/10.1038/s41467-023-39404-6
RBRC00733
RBRC03108 CASP/1Nga
Watanabe N, Hirose M, Hasegawa A, Mochida K, Ogura A, Inoue K.
Derivation of embryonic stem cells from wild-derived mouse strains by nuclear transfer using peripheral blood cells.
Sci Rep. 2023 Jul 10;13(1):11175. doi: 10.1038/s41598-023-38341-0.
https://doi.org/10.1038/s41598-023-38341-0
RBRC04944 B6.129S4-Il5<tm1.1Ktk>
Yamada T, Tatematsu M, Takasuga S, Fuchimukai A, Yamagata K, Seki S, Kuba K, Yoshida H, Taniuchi I, Bernhardt G, Shibuya K, Shibuya A, Yamada T, Ebihara T.
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy.
J Exp Med. 2023 Jul 3;220(7):e20222005. doi: 10.1084/jem.20222005.
https://doi.org/10.1084/jem.20222005
RBRC01672 RR/Sgn
Suto J.
Genetic Dissection of Litter-size Quantitative Trait Loci Located on Murine Chromosome 7.
JARQ. 2023 Jul 3;57(3):231-9. doi: 10.6090/jarq.57.231.
https://doi.org/10.6090/jarq.57.231
RBRC01461 FVB/N-Tg(Mbp-cre)9Gvn/GvnRbrc
Oizumi H, Miyamoto Y, Seiwa C, Yamamoto M, Yoshioka N, Iizuka S, Torii T, Ohbuchi K, Mizoguchi K, Yamauchi J, Asou H.
Lethal Adulthood Myelin Breakdown by Oligodendrocyte-specific Ddx54 Knockout.
iScience. 2023 Jul 21:107448. doi: 10.1016/j.isci.2023.107448.
https://doi.org/10.1016/j.isci.2023.107448
RBRC00267 C57BL/6-Tg(CAG-EGFP)C14-Y01-FM131Osb
Shinotsuka T, Miyazawa T, Karasawa K, Ozeki Y, Yasui M, Nuriya M.
Stimulated Raman scattering microscopy reveals a unique and steady nature of brain water dynamics
Cell Reports Methods. 2023 Jul 5;3(7):100519. doi: 10.1016/j.crmeth.2023.100519.
https://doi.org/10.1016/j.crmeth.2023.100519
RBRC06343 C57BL/6-App<tm2(NL-F)Tcs>
Mowry FE, Espejo-Porras F, Jin S, Quadri Z, Wu L, Bertolio M, Jarvis R, Reynolds C, Alananzeh R, Bieberich E, Yang Y.
Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice.
Neurobiol Dis. 2023 Aug;184:106213. doi: 10.1016/j.nbd.2023.106213.
https://doi.org/10.1016/j.nbd.2023.106213
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| New Collaborative papers
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Tamari T, Ikeda Y, Morimoto K, Kobayashi K, Mizuno-Iijima S, Ayabe S, Kuno A, Mizuno S, Yoshiki A.
A universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporation.
Biol Open. 2023;12 (9):bio059970. doi: 10.1242/bio.059970.
https://doi.org/10.1242/bio.059970
Inada A, Yasunami Y, Yoshiki A, Nabeshima Y, Inada O.
Greb1 Transiently Accelerates Pancreatic β-Cell Proliferation in Diabetic Mice Exposed to Estradiol.
Am J Pathol. 2023 Aug;193(8):1081-1100. doi: 10.1016/j.ajpath.2023.04.012.
https://doi.org/10.1016/j.ajpath.2023.04.012
Yamada M, Nitta Y, Uehara T, Suzuki H, Miya F, Takenouchi T, Tamura M, Ayabe S, Yoshiki A, Maeno A, Saga Y, Furuse T, Yamada I, Okamoto N, Kosaki K, Sugie A.
Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences.
Eur J Med Genet. 2023 Aug;66(8):104804. doi: 10.1016/j.ejmg.2023.104804.
https://doi.org/10.1016/j.ejmg.2023.104804
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| Newly deposited mouse strains
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Dr. Katsuaki Sato, University of Miyazaki
RBRC11949 C57BL/6-Tg(Itgae-HBEGF/EGFP)1Ksat
Dr. Wakako Fujita, Nagasaki University
RBRC12062 C57BL/6-Rtp4<tm1.1Ksak>
https://mus.brc.riken.jp/en/mailnews/kitaku_list/20230821_k/
Dr. Kazutoshi Mori, Kyoto University
RBRC11917 B6.129-Atf6<tm1Kamo>
RBRC11918 B6.129-Atf6b<tm1Kamo>
Dr. Tomoaki Shirao, Gunma University
RBRC12080 C57BL/6N-Zmynd8<tm1.2Ksak>
https://mus.brc.riken.jp/en/mailnews/kitaku_list/20230720_k
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__________________________________________________________________
RIKEN BioResource Research Center
Experimental Animal Division
3-1-1 Koyadai, Tsukuba-shi
Ibaraki, 305-0074 Japan
animal.brc@riken.jp
https://mus.brc.riken.jp/en/
__________________________________________________________________
2023.09.13.
