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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

Apr 2005 A Model for Congenital Alopecia


April 2005
Mouse of the Month

A Model for Congenital Alopecia

Novel hairless allele created by ENU mutagenesis in Korea

Chemically-induced mutation, hairless, recessive, Chr 14
Gene Symbol: Hr
Human homolog: HR (OMIM602302)
BRC No. RBRC-KIT0028 (KITOX-BM15-Mu)
Strain name: BALB/c-Hrhr-KITOX-BM15-Mu
mn050420_0301
Research Application: Dermatology, Immunology and Inflammation Research, Cancer Research, Toxicology Research

This strain was created by ENU mutagenesis program in Korea Institute of Toxicology (KIT) in Korea Research Institute of Chemical Tech. Mice resembles hairless rhino mice in which no hair regeneration occurs and skin tissue is extensively folded as shown in the Figure. A mutation in the human homolog of Hr (HR; OMIM602302) , are known to cause congenital hairless disease, alopecia universalis congenita (OMIM602302). The Depositors are welcome to collaborate further detailed analyses on this mutant mouse. Series of other ENU-mutant mice with interesting phenotypes have also been deposited to RIKEN BRC.

 

DEPOSITOR: Drs. Chang-Woo Song and Jae-Woo Cho

For further information:
Please contact with Dr. Jae-Woo Cho at email address: cjwoo@kitox.re.kr