 |
June 2006 Mouse of the Month |
| Cre Transgenic Mouse Series_1 |
Cre recombinase is a 38 kDa enzyme derived from the bacteriophage P1 which specifically recognizes 34 bp loxP sites. Cre has been shown to effectively mediate the excision of DNA flanked by loxP sites. Cre-loxP system is a very useful tool for time-space-specific knock-out the genes which can not be investigated in adults because of their embryonic lethality in conventional gene-targetting.
 BRC No. 01153 Six3-Cre mouse |
Six3-Cre | Promoter | : | Sine oculis-related homeobox 3 | ||
| Application | : | Neurobiology | ||||
| Expression | : | developing retina and ventral forebrain | ||||
| Depositor | : | Dr. Yasuhide Furuta (Univ. of Texas) |
||||
| BRC No. 01153 TgN(Six3 Cre)22Frt | ||||||
| BRC No. 01154 TgN(Six3 Cre)69Frt | ||||||
 BRC No. 01297 DBH-Cre mouse |
DBH-Cre | Promoter | : | Dopamin beta hydroxylase | ||
| Application | : | Neurobiology | ||||
| Expression | : | typical noradrenergic and adrenergic cell groups, transient catecholaminergic cell types | ||||
| Depositor | : | Dr. Kazuto Kobayashi (Fukushima Medical Univ.) |
||||
| BRC No. 01297 DBH-Cre/6-8 | ||||||
| BRC No. 01492 DBH-Cre/9-9 | ||||||
 BRC No. 01342 Emx1-Cre mouse |
Emx1-Cre | Promoter | : | Empty spiracles homolog 1 | ||
| Application | : | Neurobiology | ||||
| Expression | : | dorsal telencephalon, neocortex, hippocampus, and olfactory bulb | ||||
| Depositor | : | Dr. Shigeyoshi Itohara (RIKEN BSI) |
||||
| BRC No. 00808 Emx1-Cre | ||||||
| BRC No. 01342 Emx1-Cre Tg1 | ||||||
| BRC No. 01343 Emx1-Cre Tg2 | ||||||
| BRC No. 01344 Emx1-Cre Tg3 | ||||||
| BRC No. 01345 Emx1-Cre KI Δneo | ||||||
