2012年のノーベル医学生理学賞は「成熟した細胞を、多能性を持つ状態に初期化できること」を発見した、京都大学iPS細胞研究所長の山中伸弥教授と、英国ケンブリッジ大学のジョン・ガードン博士が受賞しました。山中教授らのグループは2006年に、マウスの線維芽細胞にOct3/4、Sox2、c-Myc、Klf4の4つの因子を強制的に発現させることで、人工多能性幹細胞（iPS細胞）を作製することに成功しました。2007年には同様の手法を用いて、ヒトの線維芽細胞からiPS細胞を樹立することに成功し、今回の受賞につながりました。
理研バイオリソースセンターは、山中教授から多数のマウスおよびヒト細胞リソースを寄託いただき、国内外の研究機関に提供しています。実験動物開発室では、iPS細胞が作製できる線維芽細胞を単離するためのツールである、Nanog-GFPトランスジェニックマウス（RBRC02290）を始めとした下記のマウスを提供しています。また、マウスおよびヒト由来のiPS細胞は、細胞材料開発室から提供しておりますので、こちらをご参照ください。
(2012/10/09)
| BRC No. | Type | Strain Name | Gene(s) | Research Application(s) |
|---|---|---|---|---|
| RBRC05521 | Transgene | B6(Cg)-Tg(ECAT15-1/ECAT15-2-EGFP)1Yam | EGFP (Green Fluorescent Protein),Frt (yeast FRT (flippase recombination target) sites) | |
| RBRC01968 | Targeted Mutation | B6.129S4-Visfatin<tm1Yam> | IRES (internal ribosomal entry site (EMCV)),Pbef1 (pre-B-cell colony-enhancing factor 1),lacZ (beta-galactosidase (E. coli)),neo (neomycin resistance gene (E. coli)) | Developmental Biology Research |
| RBRC03077 | Targeted Mutation Congenic | B6.Cg-ECAT15-1 ECAT15-2 | Dppa2 (developmental pluripotency associated 2),Dppa4 (developmental pluripotency associated 4),frt (yeast FRT (flippase recombination target) sites),loxP (phage P1 loxP) | |
| RBRC05519 | Targeted Mutation | B6;129S4(Cg)-ECAT15-1 ECAT15-2 | Dppa2 (developmental pluripotency associated 2),Dppa4 (developmental pluripotency associated 4),frt (yeast FRT (flippase recombination target) sites),loxP (phage P1 loxP) | |
| RBRC05520 | Targeted Mutation | B6;129S4(Cg)-ECAT15-1 ECAT15-2 | Dppa2 (developmental pluripotency associated 2),Dppa4 (developmental pluripotency associated 4),frt (yeast FRT (flippase recombination target) sites),loxP (phage P1 loxP) | |
| RBRC02326 | Targeted Mutation | B6;129S4-Ecat8<tm1Yam> | IRES (internal ribosomal entry site (EMCV)),Tdrd12 (tudor domain containing 12),lacZ (beta-galactosidase (E. coli)),neo (neomycin resistance gene (E. coli)),poly A (SV40 poly A) | Cell Biology Research,Developmental Biology Research |
| RBRC05478 | Targeted Mutation | B6;129S4-ECAT11 | L1td1 | |
| RBRC05518 | Targeted Mutation | B6;129S4-ECAT15-1 ECAT15-2 | Dppa2 (developmental pluripotency associated 2),Dppa4 (developmental pluripotency associated 4),Hyg (hygromycin phasphotransferase (E. coli)),frt (yeast FRT (flippase recombination target) sites),loxP (phage P1 loxP),neo (neomycin resistance gene (E. coli)) | |
| RBRC01966 | Targeted Mutation | B6;129S4-ERas<tm1Yam> | Eras (ES cell-expressed Ras),IRES (internal ribosomal entry site (EMCV)),lacZ (beta-galactosidase (E. coli)),neo (neomycin resistance gene (E. coli)) | |
| RBRC01965 | Targeted Mutation | B6;129S4-Fbxo15<tm1Yam> | Fbxo15 (F-box protein 15),IRES (internal ribosomal entry site (EMCV)),lacZ (beta-galactosidase (E. coli)),neo (neomycin resistance gene (E. coli)) | Developmental Biology Research |
| RBRC01967 | Targeted Mutation | B6;129S4-Nanog<tm1Yam> | IRES (internal ribosomal entry site (EMCV)),Nanog (Nanog homeobox),lacZ (beta-galactosidase (E. coli)),neo (neomycin resistance gene (E. coli)) | Developmental Biology Research |
| RBRC01969 | Targeted Mutation and Transgene | STOCK Tg(CAG-EGFP)1Yam Fbxo15tm1Yam | Fbxo15 (F-box protein 15),GFP (Green Fluorescent Protein (Jellyfish)),IRES (internal ribosomal entry site (EMCV)),lacZ (beta-galactosidase (E. coli)),neo (neomycin resistance gene (E. coli)) | Developmental Biology Research |
| RBRC02290 | Transgene | STOCK Tg(Nanog-GFP,Puro)1Yam | GFP (Green Fluorescent Protein (Jellyfish)),IRES (internal ribosomal entry site (EMCV)),frt (yeast FRT (flippase recombination target) sites),poly A (bovine growth hormone poly adenylation signal sequence),puro (puromycin (Streptomyces alboniger)) | Developmental Biology Research,Cell Biology Research,Fluorescent Proteins/lacZ System,FLP/frt system |
