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Bcl6 reporter mice for immune memory research B6.Cg-Bcl61<tm1.1Toka> (RBRC10015)
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Immune memory is the immune system to produce a higher-affinity antibody rapidly for antigens which have been exposed previously. This system is utilized at vaccination, and so on. However, the dynamic mechanism is little known. The transcription factor B–cell lymphoma 6 (Bcl6) reporter mice was established for elucidation of antibody production mechanism in vivo. Immune memory occurs at the germinal center (GC), which is formed in the secondary lymphoid organs for immune response. Bcl6 regulates the development of both GC B cells and follicular helper T (Tfh) cells in the GC. |
| Depositor | : | Takaharu Okada, Ph.D. Laboratory for Tissue Dynamics RIKEN Center for Integrative Medical Sciences |
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| Strain name | : | B6.Cg-Bcl6<tm1.1Toka> | |
| RBRC No. | : | RBRC10015 | |
| References | : | [1] | Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, Okada T. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity.; 34(6): 961-972, 2011. |
| [2] | Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, Kurosaki T. T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.Immunity.; 48(4): 702-715, 2018. | ||
| January 2019 Contact: Saori Mizuno, Ph.D. Experimental Animal Division, RIKEN BioResource Research Center All materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content. |
