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Cre Transgenic Mouse Series_2
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| Cre recombinase is a 38 kDa enzyme derived from the bacteriophage P1 which specifically recognizes 34 bp loxP sites. Cre has been shown to effectively mediate the excision of DNA flanked by loxP sites. Cre-loxP system is a very useful tool for time-space-specific knock-out the genes which can not be investigated in adults because of their embryonic lethality in conventional gene-targetting. |
P7 seminiferous tubules.
Blue, recombined spermatogonia. |
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| *CreER is tamoxifen-inducible Cre recombinase/Estrogen receptor fusion protein.To See other Cre transgenic mice |
