Cre Transgenic Mouse Series_2

RIKEN BRC July 2006
Mouse of the Month
Cre Transgenic Mouse Series_2
Cre recombinase is a 38 kDa enzyme derived from the bacteriophage P1 which specifically recognizes 34 bp loxP sites. Cre has been shown to effectively mediate the excision of DNA flanked by loxP sites. Cre-loxP system is a very useful tool for time-space-specific knock-out the genes which can not be investigated in adults because of their embryonic lethality in conventional gene-targetting.
P7 seminiferous tubules.
Blue, recombined spermatogonia.
Promoter : Neurogenin 3
Application : Developmental Biology
Expression : Spermatogenesis (spermatogonia) Pancreatic/enteric endocrine precursors
Depositor : Dr. Shosei Yoshida (Kyoto University)
References : Dev. Biol. 269, 447 (2004)
Development 133, 1495 (2006)
BRC No. 01456 ngn3/Cre transgenic mouse
Promoter : Olig2
Application : Neurobiology
Expression : Motoneuron and Oligodendrocyte progenitors
Depositor : Dr. Hirohide Takebayashi (National Institute for Physiological Sciences)
References : Curr. Biol.12, 1157 (2002)
Dev. Biol. 293, 358 (2006)
BRC No. 01507 Olig2-CreER knock in mouse
 *CreER is tamoxifen-inducible Cre recombinase/Estrogen receptor fusion protein.To See other Cre transgenic mice