Mar 2009 Fucci mice for visualizing cell-cycle in vivo | -実験動物開発室- (RIKEN BRC)

Fucci mice for visualizing cell-cycle in vivo

B6.Cg-Tg(Fucci)504Bsi RBRC 02706

B6.Cg-Tg(Fucci)596Bsi RBRC 02707

mn0903_0101

Two transgenic strains of fluorescent, ubiquitination-based cell cycle indicator, “Fucci”, B6.Cg-Tg(Fucci)504Bsi (RBRC02706) and B6.Cg-Tg(Fucci)596Bsi (RBRC02707) mice can be used to clearly visualize the cell cycle with fluorescence, i.e. S/G₂/M phase nuclei green and those in G₁ phase red in vivo. The double transgenic mice in which every cell nucleus exhibits either green or red fluorescence will serve as a powerful tool for visualizing the spatio-temporal dynamics of cell-cycle progression in every biological event [1].

Developer	:	Dr. Asako Sakaue-Sawano & Dr. Atsushi Miyawaki (RIKEN) http://cfds.brain.riken.jp/Fucci.html
Depositor	:	Amalgaam(MBL) https://ruo.mbl.co.jp/product/flprotein/fucci.html
Reference	:	Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., Imamura, T., Ogawa, M., Masai, H. and Miyawaki, A. 2008. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132: 487-498.