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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

May 2008 TH-GFP Transgenic Mouse


mouse_of_month_200805

TH-GFP Transgenic Mouse
A Model for Visualizing Dopamine Neurons

BRC No. RBRC02095_B6.Cg-Tg(TH-GFP)21-31
Research Application:Neurobiology Research

RBRC02095 B6.Cg-Tg(TH-GFP)21-31

GFP fluorescence in dopamine neurons of 12 weeks-old TH-GFP mice. (Coronal section of the ventral midbrain. Scale bar, 200 μm.)

 

Dopamine is a neurotransmitter which mediates motor control, cognition, emotion, reward, and neuroendocrine functions. Dysfunction of dopamine-producing neurons in the midbrain is involved in some neurological and neuropsychiatric diseases such as Parkinsonfs disease and schizophrenia. These dopamine neurons express tyrosine hydroxylase (TH), a key enzyme of catecholamine biosynthesis. The TH-GFP transgenic mouse was generated to express GFP in the majority of midbrain dopamine neurons under the control of the rat TH gene promoter. This transgenic mouse is useful for visualizing dopamine neurons to study the physiology and pathogenesis of dopamine neurons.

 

Depositor : Dr. Kazuto Kobayashi
Reference : J. Neurochem. 82: 295-304 (2002).